Active
Novel Involvement of eNAMPT/TLR4 Signaling in PAH Vascular Remodeling and Right Ventricular Dysfunction
NIH/NHLBI – R01HL141387 (2025-2029)
This application will assess the utility of a novel monoclonal antibody (ALT-100 mAb) that neutralizes the novel PAH target, eNAMPT, to address the unmet need for novel PAH therapeutics.
Role: Co-Principal Investigator (MPI)
Coronary Endothelial Cell Dysfunction in Diabetes: Role of MFGE8
NIH/NHLBI – R01HL142214 (2024-2028)
This study aims to define the role of MFGE8 in coronary microvascular disease in diabetes.
Role: Principal Investigator and Contact PI (MPI)
Coronary Microvascular Disease in Diabetes: Role of NAMPT
DOD/PRMRP – W81XWH2110472 (2021-2026)
This study is aimed to identify the role of NAMPT in the development of coronary microvascular disease in diabetes.
Role: Principal Investigator
Ion Channels and Membrane Receptors in Pulmonary Arterial Hypertension
NIH/NHLBI – R35HL171538 (2024-2031)
Ion Channels and Membrane Receptors in Pulmonary Arterial Hypertension
The goal of this study is to define the pathogenic roles of membrane receptors and ion channels in the development and progression of pulmonary arterial hypertension. Specifically, we aim to determine the molecular mechanisms by which G protein-coupled receptor functionally interacts with TRP channels and K+ channels to enhance intracellular Ca2+ signaling and cause sustained pulmonary vasoconstriction and vascular remodeling.
Role: Co-Investigator
Competed
Endothelium-driven signaling network in the development of pulmonary hypertension
NIH/NHLBI – R01HL154754 (2020-2025)
Endothelium-driven Signaling Network in the Development of Pulmonary Hypertension This study is designed to investigate the role of endothelial NOX-DHFR signaling cascade in the development of pulmonary hypertension.
Role: Co-Principal Investigator (MPI)
Role of Gap Junction in Hypoxia-induced Pulmonary Hypertension
NIH/NHLBI – R01HL146764 (2019-2024)
This grant aims to investigate the role of Gap junction in the development and progression of hypoxia-induced pulmonary hypertension.
Role: Principal Investigator
Coronary Endothelial Cell Dysfunction in Diabetes: Role of HuR
NIH/NHLBI – R01HL142214 (2018-2023)
The major goal of this study is to define the pathological role of RNA-binding protein, HuR, in coronary endothelial dysfunction in diabetes.
Role: Principal Investigator
Cellular and Molecular Mechanisms of Coronary Endothelial Dysfunction in Diabetes
NIH/NHLBI – R01HL115578 (2012-2017)
The primary goal of this project is to define the pathological role of Ca2+ homeostasis of the endoplasmic reticulum in coronary endothelial cell dysfunction in diabetes.
Role: Principal Investigator
Molecular Mechanisms of Downregulated Kv Channels in IPAH: Role of microRNA
NIH/NIDDK – R01HL115014 (2012-2017)
This study aims to investigate microRNA-mediated posttranscriptional regulation of voltage-gated K+ channel gene expression and its relationship to the development and progression of pulmonary
Role: Co-Investigator
Ca2+ Signaling in Pulmonary Arterial Hypertension: Role of CaSR
NIH/NIDDK – R01HL066012 (2013-2017)
The goal of this study is to examine whether the functional interaction of CaSR and cation channels in pulmonary arterial smooth muscle cells contributes to the development and progression of pulmonary vascular remodeling in patients with pulmonary arterial hypertension and animals with experimental pulmonary hypertension.
Role: Co-Investigator
Mechanisms of Coronary Endothelial Dysfunction in Diabetes
NIH/NIDDK – K01DK083506 (2009-2012)
The major goal of this project is to investigate the molecular mechanisms of coronary endothelial cell dysfunction in diabetes.
Role: Principal Investigator